Familial aggregation of Parkinson's disease in a multiethnic community‐based case‐control study
Identifieur interne : 000719 ( Main/Exploration ); précédent : 000718; suivant : 000720Familial aggregation of Parkinson's disease in a multiethnic community‐based case‐control study
Auteurs : Michael Y. Shino [États-Unis] ; Valerie Mcguire [États-Unis] ; Stephen K. Van Den Eeden [États-Unis] ; Caroline M. Tanner [États-Unis] ; Rita Popat [États-Unis] ; Amethyst Leimpeter [États-Unis] ; Allan L. Bernstein [États-Unis] ; Lorene M. Nelson [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-11-15.
English descriptors
Abstract
To assess the familial aggregation of Parkinson's disease (PD), we compared the cumulative incidence of PD among first‐degree relatives of PD cases and controls. We identified newly diagnosed patients with PD (n = 573) during 1994 to 1995 within Kaiser Permanente Medical Care Program of Northern California and recruited 496 cases (87%) for the case‐control study. Of 720 eligible controls matched by birth year and sex to cases, 541 (75%) agreed to participate. Information on family history of PD and other neurodegenerative diseases was obtained by in‐person structured interview. We used the reconstructed cohort approach that provides a better estimate of the risk. The cumulative incidence of PD was significantly higher among relatives of PD patients compared with relatives of controls (2.0 vs. 0.7%; relative risk (RR) = 3.4, 95% confidence interval (CI) 1.9–5.9; P = 0.0001). The degree of familial aggregation was higher among first‐degree relatives of Hispanic PD cases compared with Hispanic controls (3.7% vs. 0.4%; RR = 8.5, 95% CI 1.0–68.9) than it was among non‐Hispanic Caucasian cases and controls (2.0% vs. 0.8%; RR = 2.7, 95% CI 1.5–5.1; P = 0.02). The familial aggregation of PD was stronger among the siblings of PD cases (RR = 5.4, 95% CI 1.8–16.0) than among parents (RR = 2.7, 95% CI 1.3–5.2). The incidence and familial aggregation of PD is highest among Hispanics, warranting further studies of genetic and environmental risk factors in the Hispanic population. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23361
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Familial aggregation of Parkinson's disease in a multiethnic community‐based case‐control study</title><author><name sortKey="Shino, Michael Y" sort="Shino, Michael Y" uniqKey="Shino M" first="Michael Y." last="Shino">Michael Y. Shino</name></author><author><name sortKey="Mcguire, Valerie" sort="Mcguire, Valerie" uniqKey="Mcguire V" first="Valerie" last="Mcguire">Valerie Mcguire</name></author><author><name sortKey="Van Den Eeden, Stephen K" sort="Van Den Eeden, Stephen K" uniqKey="Van Den Eeden S" first="Stephen K." last="Van Den Eeden">Stephen K. Van Den Eeden</name></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name></author><author><name sortKey="Popat, Rita" sort="Popat, Rita" uniqKey="Popat R" first="Rita" last="Popat">Rita Popat</name></author><author><name sortKey="Leimpeter, Amethyst" sort="Leimpeter, Amethyst" uniqKey="Leimpeter A" first="Amethyst" last="Leimpeter">Amethyst Leimpeter</name></author><author><name sortKey="Bernstein, Allan L" sort="Bernstein, Allan L" uniqKey="Bernstein A" first="Allan L." last="Bernstein">Allan L. Bernstein</name></author><author><name sortKey="Nelson, Lorene M" sort="Nelson, Lorene M" uniqKey="Nelson L" first="Lorene M." last="Nelson">Lorene M. Nelson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:11D1CEA0D26146D8925CC9EC4E7265AD278D9C39</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23361</idno><idno type="url">https://api.istex.fr/document/11D1CEA0D26146D8925CC9EC4E7265AD278D9C39/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000F58</idno><idno type="wicri:Area/Main/Curation">000D77</idno><idno type="wicri:Area/Main/Exploration">000719</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Familial aggregation of Parkinson's disease in a multiethnic community‐based case‐control study</title><author><name sortKey="Shino, Michael Y" sort="Shino, Michael Y" uniqKey="Shino M" first="Michael Y." last="Shino">Michael Y. Shino</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Current Address: UCLA Med‐Pulmonary and Critical Care, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mcguire, Valerie" sort="Mcguire, Valerie" uniqKey="Mcguire V" first="Valerie" last="Mcguire">Valerie Mcguire</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Van Den Eeden, Stephen K" sort="Van Den Eeden, Stephen K" uniqKey="Van Den Eeden S" first="Stephen K." last="Van Den Eeden">Stephen K. Van Den Eeden</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Research, Kaiser Foundation Research Institute, Oakland, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Parkinson's Institute, Sunnyvale, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Popat, Rita" sort="Popat, Rita" uniqKey="Popat R" first="Rita" last="Popat">Rita Popat</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Leimpeter, Amethyst" sort="Leimpeter, Amethyst" uniqKey="Leimpeter A" first="Amethyst" last="Leimpeter">Amethyst Leimpeter</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Research, Kaiser Foundation Research Institute, Oakland, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bernstein, Allan L" sort="Bernstein, Allan L" uniqKey="Bernstein A" first="Allan L." last="Bernstein">Allan L. Bernstein</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kaiser Santa Rosa Medical Center, Santa Rosa, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nelson, Lorene M" sort="Nelson, Lorene M" uniqKey="Nelson L" first="Lorene M." last="Nelson">Lorene M. Nelson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-11-15">2010-11-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="2587">2587</biblScope><biblScope unit="page" to="2594">2594</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">11D1CEA0D26146D8925CC9EC4E7265AD278D9C39</idno><idno type="DOI">10.1002/mds.23361</idno><idno type="ArticleID">MDS23361</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>case‐control</term><term>epidemiology</term><term>family history</term><term>risk factors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the familial aggregation of Parkinson's disease (PD), we compared the cumulative incidence of PD among first‐degree relatives of PD cases and controls. We identified newly diagnosed patients with PD (n = 573) during 1994 to 1995 within Kaiser Permanente Medical Care Program of Northern California and recruited 496 cases (87%) for the case‐control study. Of 720 eligible controls matched by birth year and sex to cases, 541 (75%) agreed to participate. Information on family history of PD and other neurodegenerative diseases was obtained by in‐person structured interview. We used the reconstructed cohort approach that provides a better estimate of the risk. The cumulative incidence of PD was significantly higher among relatives of PD patients compared with relatives of controls (2.0 vs. 0.7%; relative risk (RR) = 3.4, 95% confidence interval (CI) 1.9–5.9; P = 0.0001). The degree of familial aggregation was higher among first‐degree relatives of Hispanic PD cases compared with Hispanic controls (3.7% vs. 0.4%; RR = 8.5, 95% CI 1.0–68.9) than it was among non‐Hispanic Caucasian cases and controls (2.0% vs. 0.8%; RR = 2.7, 95% CI 1.5–5.1; P = 0.02). The familial aggregation of PD was stronger among the siblings of PD cases (RR = 5.4, 95% CI 1.8–16.0) than among parents (RR = 2.7, 95% CI 1.3–5.2). The incidence and familial aggregation of PD is highest among Hispanics, warranting further studies of genetic and environmental risk factors in the Hispanic population. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Shino, Michael Y" sort="Shino, Michael Y" uniqKey="Shino M" first="Michael Y." last="Shino">Michael Y. Shino</name></region><name sortKey="Bernstein, Allan L" sort="Bernstein, Allan L" uniqKey="Bernstein A" first="Allan L." last="Bernstein">Allan L. Bernstein</name><name sortKey="Leimpeter, Amethyst" sort="Leimpeter, Amethyst" uniqKey="Leimpeter A" first="Amethyst" last="Leimpeter">Amethyst Leimpeter</name><name sortKey="Mcguire, Valerie" sort="Mcguire, Valerie" uniqKey="Mcguire V" first="Valerie" last="Mcguire">Valerie Mcguire</name><name sortKey="Nelson, Lorene M" sort="Nelson, Lorene M" uniqKey="Nelson L" first="Lorene M." last="Nelson">Lorene M. Nelson</name><name sortKey="Popat, Rita" sort="Popat, Rita" uniqKey="Popat R" first="Rita" last="Popat">Rita Popat</name><name sortKey="Shino, Michael Y" sort="Shino, Michael Y" uniqKey="Shino M" first="Michael Y." last="Shino">Michael Y. Shino</name><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name><name sortKey="Van Den Eeden, Stephen K" sort="Van Den Eeden, Stephen K" uniqKey="Van Den Eeden S" first="Stephen K." last="Van Den Eeden">Stephen K. Van Den Eeden</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000719 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000719 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:11D1CEA0D26146D8925CC9EC4E7265AD278D9C39
|texte= Familial aggregation of Parkinson's disease in a multiethnic community‐based case‐control study
}}
| This area was generated with Dilib version V0.6.23. |  |